Solid Dispersions of Medamine and Albendazole with Water-soluble Polymers: Preparation and Propertiesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 декабря 2020 г.
Аннотация:Solid dispersions of medamine and albendazole with water-soluble polymers (PVP, arabinogalactan) were obtainedby mechanochemical technology to increase the aqueous solubility of poorly soluble anthelmintic drugsubstances. An analysis of solid dispersions of drug–polymer systems showed that their solubilities dependedon the nature of both the drug and polymer. The aqueous solubilities of medamine and albendazole could beincreased by greater than 50 and 27 times, respectively, by varying the joint processing time with the polymers.An analysis of IR spectra and a comparison of them with published data suggested that intermolecularcomplexes were formed in these systems. Innovative anthelmintic drugs with increased solubility for medicineand veterinary medicine could be created by using the proposed mechanochemical technology for obtainingsolid dispersions. The resulting solid dispersions had several advantages over conventional dosage forms,in particular, they were obtained in one stage, their preparation did not require excipients (dispersants, surfactants,wetting agents, etc.), and they were more conveniently used and inexpensively priced.