The Evaluation of the Hemocompatibility of Polymer Membrane Materials for Blood Oxygenation

Alentiev, A.Y.; Bogdanova, Y.G.; Dolzhikova, V.D.; Belov, N.A.; Nikiforov, R.Y.; Alentiev, D.A.; Karpov, G.O.; Bermeshev, M.V.; Borovkova, N.V.; Evseev, A.K.; Makarov, M.S.; Goroncharovskaya, I.V.; Storozheva, M.V.; Zhuravel, S.V.

Авторы: Alentiev A.Yu, Bogdanova Yu G., Dolzhikova V.D., Belov N.A., Nikiforov R.Yu, Alentiev D.A., Karpov G.O., Bermeshev M.V., Borovkova N.V., Evseev A.K., Makarov M.S., Goroncharovskaya I.V., Storozheva M.V., Zhuravel S.V.
Журнал: Membranes and Membrane Technologies
Том: 2
Номер: 6
Год издания: 2020
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 368
Последняя страница: 382
DOI: 10.1134/S2517751620060025
Аннотация: A comprehensive interdisciplinary study is performed for 12 polymers promising for the fabrication of membranes for extracorporeal membrane oxygenation based on them by methods of gas permeability, wetting, piezoelectric microweighing, and direct biomedical methods for determining hemocompatibility of whole blood from healthy donors. It is found that trimethylsilyl-substituted polytricyclononene, polyhexafluoropropylene, and semicrystalline polyphenylene oxide are the best polymer materials for the diffusion membranes of oxygenators. It is shown that traditional approaches that associate the surface properties of polymers (water wettability, plasma protein adsorption, energy characteristics of surfaces) with their hemocompatibility do not provide precise correlations with the biomedical methods based on the analysis of the changes in the shape of blood cells as a result of adhesion on the surface of the polymer. The complexity of the mechanism of interaction of the surface of polymers with blood also does not allow for clear structure– property correlations traditional for membrane gas separation. The directions of further research in this area are defined.
Добавил в систему: Богданова Юлия Геннадиевна

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The Evaluation of the Hemocompatibility of Polymer Membrane Materials for Blood Oxygenationстатья

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