Molecular design and synthesis of new heterobivalent compounds based on chlorambucil and colchicineстатья
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Дата последнего поиска статьи во внешних источниках: 10 февраля 2021 г.
Аннотация:Two new heterobivalent molecules were designed by linking of DNA-alkylating agent chlorambucil with tubulin-targeted compound colchicine or its adamantyl bearing C7-derivative. Target compounds were synthesized via acid coupling with N-deacetylcolchicine. According to preliminary biotests both conjugates cause depolymerization of cellular microtubules and strong tubulin clustering, colchicine–chlorambucil conjugate being one order of magnitude more potent and exhibiting some selectivity to carcinoma A549 cells.