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HUMAN PARP1 UNFOLDS NUCLEOSOMES AND FACILITATES TRANSCRIPTION THROUGH CHROMATIN BY POL IIтезисы доклада
- Авторы: Kotova Elena, Maluchenko Natalia V., Pascal John M., Feofanov Alexey V., Studitsky Vasily M.
- Сборник: THE PARP FAMILY and ADP-RIBOSYLATION
- Серия: Abstracts of papers presented at the 2020 virtual meeting
- Тезисы
- Глава в коллективной монографии
- Год издания: 2020
- Издательство: Cold Spring Harbor Laboratory
- Местоположение издательства: Cold Spring Harbor, NY, United States
- Первая страница: 116
- Последняя страница: 116
- Аннотация: Before transcription, PARP1 binding to nucleosomes containing double-strandDNA breaks (DSBs) induces an uncoiling of nucleosomal DNA (4).Twodistinct types of PARP1 binding to mononucleosomes were detected usingspFRET: binding to DSBs or binding to core nucleosome, respectively.Surprisingly, only the latter type of binding of PARP1 induces the reversibleuncoiling of nucleosomal DNA that is independent of catalytic activity ofPARP1. The data suggest that PARP1-induced nucleosome unfolding isinduced by H1-like binding of PARP1 to nucleosomes
- Добавил в систему: Малюченко Наталия Валериевна