Stabilized Nanoemulsions of Astaxanthin Esters of Known Fatty-Acid Compositionстатья
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Дата последнего поиска статьи во внешних источниках: 16 декабря 2020 г.
Аннотация:The aim of the present study was to develop astaxanthin ester nanoemulsions with phosphatidylcholine and
evaluate their stability during storage under various conditions. Monoesters were obtained by column chromatography of an oil extract of Haematococcus pluvialis and mixed astaxanthin esters. Monoester fatty-acid
compositions were determined by HPLC. A solution of astaxanthin monoesters or a mixture of astaxanthin
mono- and diesters in 5% aqueous EtOH was rapidly degraded in light at room temperature. The addition of
antioxidants such as ascorbic acid and butylated hydroxytoluene did not give significant positive results. In
contrast, simultaneous addition of albumin, which was used for these purposes for the first time, increased significantly the shelf life. The optimized conditions for producing nanoemulsions from astaxanthin esters and
phosphatidylcholine by injection gave nanoemulsions with an average particle size of 50 nm that remained
physically and chemically stable during storage for a month.