|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Cryostructuring of Polymeric Systems: 57 Spongy Wide-Porous Cryogels Based on the Proteins of Blood Serum: Preparation, Properties and Application as the Carriers of Peptide Bioregulatorsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 января 2021 г.
- Авторы: Sidorskii Egor V., Krasnov Mikhail S., Yamskova Viktoria P., Lozinsky Vladimir I.
- Журнал: GELS
- Том: 6
- Номер: 4
- Год издания: 2020
- Издательство: MDPI Publishing
- Местоположение издательства: Basel, Switzerland, Switzerland
- Первая страница: 1
- Последняя страница: 16
- Номер статьи: 50
- DOI: 10.3390/gels6040050
- Аннотация: Wide-pore proteinaceous freeze–thaw spongy gels were synthesized via the cryotropicgelation technique using the bovine blood serum or its diluted solutions as the protein-containingprecursors. The feed systems also included the denaturant (urea) and the thiol-reductant (cysteine).The gel-fraction yield decreased and the swelling degree of the walls of macropores in suchheterophase matrices increased with decreasing the initial protein concentration. The optimumfreezing temperature was found to be within a rather narrow range from −15 to −20 °C. In this case,the average size of the macropores in the resultant cryogels was 90–110 μm. The suitability of suchsoft wide-pore gel materials for the application as the carriers of peptide bioregulators wasdemonstrated in the in vitro experiments, when the posterior segments of the Pleurodeles waltl adultnewts’ eyes were used as a model biological target. It was shown that a statistically reliableprotective effect on the state of the sclera, vascular membrane and retinal pigment epithelium, aswell as on the viability of fibroblasts, was inherent in the proteinaceous cryogels loaded with thepeptide bioregulator (Viophtan-5™) isolated from the bovine eye sclera.
- Добавил в систему: Лозинский Владимир Иосифович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Crst_57.pdf | 603,2 КБ | 15 декабря 2020 [Lozinskii] |