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A mitochondrial mutational signature of temperature and longevity in ectothermic and endothermic vertebratesстатья
- Авторы: Mikhailova Alina G., Shamansky Victor, Mikhailova Alina A., Ushakova Kristina, Tretyakov Evgenii, Oreshkov Sergey, Knorre Dmitry, Polishchuk Leonard, et al.
- Журнал: bioRxiv (The preprint server for biology)
- Год издания: 2020
- DOI: 10.1101/2020.07.25.221184
- Аннотация: Mitochondrial mutational signature is very conserved and low deviations between species have been associated with longevity. By reconstructing species-specific mtDNA mutational spectrum for ray-finned fishes (Actinopterygii), we observed that temperature is a strong additional factor shaping the mtDNA mutational spectrum in ectotherms. The analysis of mammalian endotherms, with a special focus on species with temporarily or permanently low metabolic rates (hibernators, daily torpors, naked mole rat, etc.), confirmed the temperature effect, suggesting that two main factors shape between-species variation in mitochondrial mutational spectra: longevity and temperature.DOI: https://doi.org/10.1101/2020.07.25.221184
- Добавил в систему: Полищук Леонард Владимирович