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Localization and colocalization of TLR4 and TRPV1 in the enteric neuronsстатья
- Авторы: Filippova L.V., Bystrova E.Y., Malyshev F.S., Platonova O.N., Nozdrachev A.D.
- Сборник: Applied and Fundamental Studies : Proceedings of the 5th International Academic Conference
- Год издания: 2014
- Место издания: Publishing House Science and Innovation Center St. Louis, Missouri, USA
- Первая страница: 30
- Последняя страница: 35
- Аннотация: Results obtained by immunohistochemistry have shown that receptor of innate immunity TLR4 and nociceptive vanilloid receptor TRPV1 are expressed in enteric neurons of the rat duodenum, jejunum and colon. The analysis of neurons distribution in the gut ganglia revealed that vanilloid receptors are expressed by neurons localized mainly in myenteric plexus whereas TLR4-immunoreactive neurons are generally present in submucous plexus. The use of immunohistochemical method with a triple label has revealed colocalization of both receptors in the single neuron. The results suggest that receptors of innate immunity and nociceptive receptors can interact during a bacterial invasion or gut inflammatory diseases.
- Добавил в систему: Платонова Ольга Николаевна