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Protective effect of cyclosporine-A, carnitine, and Mg2+ plus ADP during Ca2+-dependent permeabilization of mitochondria by fatty-acids and during activation of NADH oxidation via an external pathwayстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
- Авторы: STARKOV AA, MARKOVA OV, MOKHOVA EN, ARRIGONIMARTELLI E., BATTELLI D., BELLEI M., BOBYLEVA VA
- Журнал: Biochemistry (Moscow)
- Том: 58
- Номер: 8
- Год издания: 1993
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 906
- Последняя страница: 914
- Аннотация: The ability of cyclosporin A, Mg2+ plus ADP and L-carnitine to enhance energy recoupling in liver mitochondria and to inhibit the induction of the external pathway of NADH oxidation during Ca(2+)-dependent oxidative phosphorylation uncoupling by palmitate has been studied. Cyclosporin A, Mg2+ plus ADP and L-carnitine plus ATP prevent with an equal efficiency the induction of the external pathway of NADH oxidation by palmitate and Ca2+ in mitochondria but differ drastically by their ability to increase the coupling in permeabilized mitochondria. The recoupling effect of cyclosporin is manifested after addition of Mg2+ plus ADP. The protective action of Mg2+ plus ADP is prevented by preincubation with carboxyatractylate. Oxidation of NADH via an external pathway results in delta psi generation, however, only in the presence of the recoupling factors. The role of the cyclosporin-sensitive pore in Ca(2+)-dependent damage of mitochondria as well as in the induction of the external pathway of NADH oxidation is discussed.
- Добавил в систему: Мохова Елена Николаевна