Phytochemical and Pharmacological Vectors from Malva Sylvestris L. for application in Dermatological Practiceстатья
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Web of Science ,
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Дата последнего поиска статьи во внешних источниках: 20 января 2021 г.
Авторы:
Terninko I.I. ,
Nemyatykh O.D. ,
Sakipova Z.B. ,
Kuldyrkaeva E.V. ,
Onishschenko U.E.
Журнал:
Pharmaceutical Chemistry Journal
Том:
50
Номер:
12
Год издания:
2017
Издательство:
Kluwer Academic/Plenum Publishers
Местоположение издательства:
United States
Первая страница:
805
Последняя страница:
809
DOI:
10.1007/s11094-017-1536-0
Аннотация:
The composition of phenolic constituents from common mallow leaves was studied by HPLC. Total flavonoids and hydroxycinnamic acids were determined quantitatively as 2.97 ± 0.08% and 2.84 ± 0.03%, respectively. Luteolin (96.12 mg/100 g) and chlorogenic acid (51.04 mg/100 g) dominated the extracted phenolic compounds. Pharmacological tests (acute exudative inflammation model, wound-tensiometry on linear incised wound model, Nesterov test) were conducted. It was established that a gel with mallow extract applied to animals with inflammatory pathologies decreased statistically significantly as compared with a control the inflammation index and exudation rate. The complex of phenolic compounds may have been responsible for this. Reparative, capillary-protective, and hydrating effects of the plant extract were also found. The obtained results provided experimental justification for treating inflammatory pathologies with mallow leaves and using this plant to treat dermatological diseases. The prerequisites for developing dosage forms from common mallow extract and introducing it into official medicine have been created. © 2017, Springer Science+Business Media New York.
Добавил в систему:
Тернинко Инна Ивановна