Synthesis and Structure of Nido-Carboranyl Azide and its “Click” Reactionsстатья
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Дата последнего поиска статьи во внешних источниках: 9 апреля 2021 г.
Аннотация:Novel zwitter-ionic nido-carboranyl azide 9-N3(CH2)3Me2N-nido-7,8-C2B9H11 was prepared by the reaction of 9-Cl(CH2)3Me2N-nido-7,8-C2B9H11 with NaN3. The solid-state molecular structure of nido-carboranyl azide was determined by single-crystal X-ray diffraction. 9-N3(CH2)3Me2N-nido-7,8-C2B9H11 was used for the copper(I)-catalyzed azide-alkyne cycloaddi-tion with phenylacetylene, alkynyl-3β-cholesterol and cobalt/iron bis(dicarbollide) terminal al-kynes to form the target 1,2,3-triazoles. The nido-carborane-cholesterol conjugate 9-3β-Chol-O(CH2)С-CH-N3(CH2)3Me2N-nido-7,8-C2B9H11 with charge-compensated group in a linker can be used as a precursor for preparation of liposomes for Boron Neutron Capture Ther-apy (BNCT). A series of novel zwitter-ionic boron-enriched cluster compounds bearing a 1,2,3-triazol-metallacarborane-carborane conjugated system was synthesized. Prepared conju-gates contain a large amount of boron atom in the biomolecule and potentially can be used for BNCT.