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INHIBITORS OF THE ATP ADP ANTIPORTER SUPPRESS STIMULATION OF MITOCHONDRIAL RESPIRATION AND H+ PERMEABILITY BY PALMITATE AND ANIONIC DETERGENTSстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: BRUSTOVETSKY NN, DEDUKHOVA VI, EGOROVA MV, MOKHOVA EN, SKULACHEV VP
- Журнал: FEBS Letters
- Том: 272
- Номер: 1-2
- Год издания: 1990
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 187
- Последняя страница: 189
- DOI: 10.1016/0014-5793(90)80480-7
- Аннотация: The action of ATP/ADP-antiporter inhibitors upon the uncoupling effect of palmitate, detergents and ‘classical’ uncouplers has been studied. The uncoupling effect was estimated by stimulation of succinate oxidation and of H+ permeability of rat liver mitochondria in the presence of oligomycin. It is shown that carboxyatractylate (CAtr) and pyridoxal 5-phosphate (PLP) suppress the uncoupling induced by palmitate and the anionic detergents SDS and cholate, but do not affect that induced by the cationic detergents CTAB, by the non-ionic detergent Triton X-100, as well as by the ‘classical’ uncouplers FCCP and DNP. The results are discussed in terms of a concept assuming that the ATP/ADP-antiporter facilitates the electrophoretic export of hydrophobic anions from mitochondria.
- Добавил в систему: Мохова Елена Николаевна