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Activation of the external pathway of NADH oxidation in liver mitochondria of cold-adapted ratsстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Mokhova E.N., Skulachev V.P., Zhigacheva I.V.
- Журнал: Biochimica et biophysica acta
- Том: 501
- Номер: 3
- Год издания: 1978
- Издательство: Elsevier Pub. Co.
- Местоположение издательства: Amsterdam, Netherlands
- Первая страница: 415
- Последняя страница: 423
- DOI: 10.1016/0005-2728(78)90109-3
- Аннотация: 15 min cold exposure of rats adapted to cold results in switching on a pathway of the fast oxidation of extramitochondrial NADH in the isolated liver mitochondria. This pathway is sensitive to mersalyl and cyanide, resistant to amytal and antimycin A, and can be stimulated by dinitrophenol. A portion of the endogenous cytochrome c pool can easily be removed by washing mitochondria of the cold-exposed rats. A scheme is discussed, postulating desorption of the inner membrane-bound cytochrome c into intermembrane space of mitochondria, resulting in formation of a link between the non-phosphorylating NADH-cytochrome c reductase in the outer mitochondrial membrane and cytochrome c oxidase in the inner membrane. It is suggested that such an oxidative pathway is involved in the urgent heat production in liver in response to the cold treatment.
- Добавил в систему: Мохова Елена Николаевна