Effect of antibodies to glutamate on caspase-3 activity in brain structures of rats with experimental Alzheimer’s diseaseстатья
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Дата последнего поиска статьи во внешних источниках: 20 сентября 2013 г.
Аннотация:Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment Aβ(25-35) into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage reduced enzyme activity in these structures in a rat model of Alzheimer’s disease.