Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy

Konnikova, M.R.; Cherkasova, O.P.; Nazarov, M.M.; Vrazhnov, D.A.; Kistenev, Y.V.; Titov, S.E.; Kopeikina, E.V.; Shevchenko, S.P.; Shkurinov, A.P.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 апреля 2021 г.

Авторы: Konnikova Maria R., Cherkasova Olga P., Nazarov Maxim M., Vrazhnov Denis A., Kistenev Yuri V., Titov Sergei E., Kopeikina Elena V., Shevchenko Sergei P., Shkurinov Alexander P.
Журнал: Biomedical optics express
Том: 12
Номер: 2
Год издания: 2021
Издательство: Optical Society of America
Местоположение издательства: United States
Первая страница: 1020
Последняя страница: 1035
DOI: 10.1364/boe.412715
Аннотация: The liquid and lyophilized blood plasma of patients with benign or malignant thyroid nodules and healthy individuals were studied by terahertz (THz) time-domain spectroscopy and machine learning. The blood plasma samples from malignant nodule patients were shown to have higher absorption. The glucose concentration and miRNA-146b level were correlated with the sample’s absorption at 1 THz. A two-stage ensemble algorithm was proposed for the THz spectra analysis. The first stage was based on the Support Vector Machine with a linear kernel to separate healthy and thyroid nodule participants. The second stage included additional data preprocessing by Ornstein-Uhlenbeck kernel Principal Component Analysis to separate benign and malignant thyroid nodule participants. Thus, the distinction of malignant and benign thyroid nodule patients through their lyophilized blood plasma analysis by terahertz time-domain spectroscopy and machine learning was demonstrated.
Добавил в систему: Шкуринов Александр Павлович

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Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopyстатья

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