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High levels of expression of p27KIP1 and cyclin E in invasive primary malignant melanomasстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 февраля 2021 г.
- Авторы: Bales Elise S., Dietrich Cheryl, Bandyopadhyay Debdutta, Schwahn Denise J., Xu Weidong, Didenko Vladimir, Leiss Paula, Conrad Nicole, Pereira-Smith Olivia, Orengo Ida, Medrano Estela E.
- Журнал: Journal of Investigative Dermatology
- Том: 113
- Номер: 6
- Год издания: 1999
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 1039
- Последняя страница: 1046
- DOI: 10.1046/j.1523-1747.1999.00812.x
- Аннотация: Cancer cells have abnormal cell cycle regulation which favors accelerated proliferation, chromosomal instability, and resistance to the senescence response. Although the p16INK4a locus is the most prominent susceptibility locus for familial melanomas, the low frequency of p16 mutations in sporadic melanomas suggests additional alterations in other cell cycle regulatory genes. Here we used primary melanoma tumors to reveal early cell cycle alterations that could be masked in advanced metastatic lesions due to their inherently high genetic instability. Unexpectedly, the cyclin-dependent kinase inhibitors p27KIP1 and/or p21Waf-1/SDI-1 were found to be expressed in 13 of 18 (72%) of the primary melanomas with a Breslow thickness greater than 0.076 mm. In general, p27 and/or p21 staining in the primary tumors correlated with low Ki-67 index. Importantly, most of the p21- and p27-positive tumors expressed...
- Добавил в систему: Didenko Vladimir Vladimirovich