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Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor functionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 февраля 2021 г.
- Авторы: Bérubé Nathalie G., Swanson Xin H., Bertram Michael J., Kittle Joseph D., Didenko Vladimir, Baskin David S., Smith James R., Pereira-Smith Olivia M.
- Журнал: Brain research. Molecular brain research
- Том: 63
- Номер: 2
- Год издания: 1999
- Издательство: Elsevier Science Publishers
- Местоположение издательства: Amsterdam, Netherlands
- Первая страница: 233
- Последняя страница: 240
- DOI: 10.1016/s0169-328x(98)00278-2
- Аннотация: Abstract We have isolated and characterized a novel cDNA, C1q-Related Factor (CRF), that is predicted to encode a 258 amino acid polypeptide with a hydrophobic signal sequence, a collagenous region, and a globular domain at the carboxy terminus that shares homology to the C1q signature domain. Human CRF transcript is expressed at highest levels in the brain, particularly in the brainstem. In situ hybridization to mouse brain sections demonstrated that CRF transcripts are most abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus. The mouse CRF homolog is highly similar to the human gene at both the nucleotide and protein level, suggesting an important conserved role for this protein.
- Добавил в систему: Didenko Vladimir Vladimirovich