Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines

Abel, A.S.; Averin, A.D.; Maloshitskaya, O.A.; Savelyev, E.N.; Orlinson, B.S.; Novakov, I.A.; Beletskaya, I.P.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.

Авторы: Abel Anton S., Averin Alexei D., Maloshitskaya Olga A., Savelyev Evgenii N., Orlinson Boris S., Novakov Ivan A., Beletskaya Irina P.
Журнал: Molecules
Том: 18
Номер: 2
Год издания: 2013
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 2096
Последняя страница: 2109
DOI: 10.3390/molecules18022096
Аннотация: Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines in which substituents at the nitrogen atom differ in bulkiness. The selectivity of the amination of 2,6-dichloroquinoline was very low, substantially better results were obtained with 2,8-dichloroquinoline, and 4,8- and 4,7-dichloroquinolines provided the best yields of the amination products. Diamination of 4,8- and 4,7-dichloroquinolines was carried out with two amines which differ strongly in the bulkiness of the alkyl group. In the majority of cases BINAP ligand was successfully applied, however, it had to be replaced with DavePhos in certain reactions when using the most sterically hindered amine as well as for the diamination reactions.
Добавил в систему: Малошицкая Ольга Александровна

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Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Aminesстатья

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