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The Emericellipsins A-E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungiстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 апреля 2021 г.
- Авторы: Kuvarina Anastasia E., Gavryushina Irina A., Kulko Alexander B., Ivanov Igor A., Rogozhin Eugene A., Georgieva Marina L., Vera S.
- Журнал: Journal of Fungi
- Том: 7
- Номер: 2
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 153
- DOI: 10.3390/jof7020153
- Аннотация: Novel antimicrobial peptides with antifungal and cytotoxic activity were derived fromthe alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this strainproduced emericellipsin A (EmiA), which has strong antifungal and cytotoxic properties. Furtheranalyses of the metabolites obtained under a special alkaline medium resulted in the isolationof four new homologous (Emi B-E). In this work, we report the complete primary structure anddetailed biological activity for the newly synthesized nonribosomal antimicrobial peptides calledemericellipsins B–E. The inhibitory activity of themajor compound, EmiA, against drug-resistantpathogenic fungi was similar to that of amphotericin B (AmpB). At the same time, EmiA had nohemolytic activity towards human erythrocytes. In addition, EmiA demonstrated low cytotoxicactivity towards the normal HPF line, but possessed cancer selectivity to the K-562 and HCT-116cell lines. Emericillipsins from the alkalophilic fungus Emericellopsis alkaline are promising treatmentalternatives to licensed antifungal drugs for invasive mycosis therapy, especially for multidrug resistant aspergillosis and cryptococcosis.
- Добавил в систему: Садыкова Вера Сергеевна
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