|
ИСТИНА |
Войти в систему Регистрация |
ИПМех РАН |
||
Neurochemical and Behavioral Changes in the Early Stage Model of Parkinsonism Induced By Intranasal Administration of MPTP to Wistar Ratsстатья
- Авторы: Berezhnoy D.S., Kulikova O.I., Fedorova T.N., Inozemtsev A.N., Stvolinsky S.L.
- Журнал: Pavlov journal of higher nervous activity
- Том: 68
- Номер: 4
- Год издания: 2018
- Издательство: Pergamon Press.
- Местоположение издательства: Oxford [Elmsford, N. Y.], England
- Первая страница: 514
- Последняя страница: 523
- Аннотация: The work characterizes biochemical parameters, behavioral activity and learning in the new ratmodel of presymptomatic stage Parkinson’s disease, induced by single intranasal MPTP administration (2mg). Experiments show the decreased motivational activity during learning in rats, treatedwith MPTP. This was not accompanied by motor disfunctions, characteristic to Parkinson’s disease, which is in line with literature data and confirms the presymptomatic stage. The activity of antioxidant system in homogenates of frontal lobe tissue in experimental animals was considerably reduced. The decrease in concentration of the main metabolites of dopamine – 3,4 dihydroxyphenylacetic and homovanillic acids – is shown in the striatum and the brainstem of experimental animals.
- Добавил в систему: Бережной Даниил Сергеевич