Copper Ions Potentiate a Decrease in the Mitochondrial Membrane Potential in Cultured Cerebellar Granule Neurons during Glucose Deprivationстатья

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Дата последнего поиска статьи во внешних источниках: 22 июля 2017 г.

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[1] Copper ions potentiate a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons during glucose deprivation / E. E. Genrikhs, E. V. Stelmashook, V. B. Turovetskii et al. // Neurochemical Journal. — 2017. — Vol. 11, no. 2. — P. 157–160. We showed that glucose deprivation for 35 min induces a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons, which was enhanced in the presence of 10 μM copper ions (Cu2+). This was associated with an increase in the free-radical level that was not affected by the noncompetitive antagonist of glutamate NMDA receptors MK-801, which prevented subsequently developing neuronal loss. However, in the presence of glucose, Cu2+ did not affect cell viability. Thus, Cu2+ induced stronger oxidative stress during glucose deprivation than in the presence of glucose, which, in turn, results in mitochondrial damage, glutamate release, glutamate receptor hyperstimulation, and neuronal loss. [ DOI ]

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