Аннотация:Peptide nanoparticles obtained by the enzymatic hydrolysis of proteins are new biocompatible nontoxic systems for transport of biologically active compounds. The formation of peptide nanoparticles from b-casein during its controlled hydrolysis by trypsin was modeled by the methods of chemical kinetics. The product of the time of nanoparticle formation (tmax) by the enzyme concentration (E0) was analyzed in different kinetic models. The dependence of tmaxE0 on enzyme concentration was used to estimate the contribution of enzymatic and non-enzymatic stages to the formation of nanoparticles.