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"Experimental study of ultrastructural mechanisms and kinetics of tegumental secretion in cestodes parasiting fish (Cestoda: Diphyllobothriidea)"статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kutyrev I.A., Biserova N.M., Mazur O.E., Dugarov Zh N.
- Журнал: Journal of Fish Diseases
- Год издания: 2021
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- DOI: 10.1111/jfd.13386
- Аннотация: AbstractThe structural response and plasticity of the cestode tegument in response to the influence of the host organism is not yet well understood. The main aims of our in vitro study were to analyse the ultrastructural mechanisms and kinetics of tegumental secretion in two cestodes species, Dibothriocephalus dendriticus and Ligula interrupta in response to the influence of fish host blood serum. The incubation of plerocercoids in the culture medium, which contained fish host blood serum, resulted in an increased number of secretory products on the tegument surface. Our study is the first to experimentally demonstrate the formation of plerocercoid protective layers influenced by the host’s internal environment factors. The mechanism of the generation of the protective layer included the following: the intensive formation of organelles in the tegumental cytons and their transfer to the distal cytoplasm of the tegument; increases in extracellular vesicles and vacuoles released on the tegument surface; arrangement of secretory products and fine-dispersed extracellular matrix in layers and formation of the protective layer. The structural tegumental response included increases in the glycocalyx layer and structural changes. Our study revealed that the universal mechanism of protective layer formation was intrinsic to different tapeworms. Hypothetically, plerocercoids of cestodes parasiting in fish may use tegumental secretion for the formation of a protective layer and for the release of immunoregulator molecules to evade of the host’s immune response.Keywords: apocrine and merocrine secretion, excretory/secretory products, extracellular matrix, glycocalyx, tapeworms, tegument.
- Добавил в систему: Бисерова Наталья Михайловна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2021-Kutyrev-Biserova_et_al-jfd.13386.pdf | 6,5 МБ | 30 апреля 2021 [nbiserova] | |
| 2. | Иллюстрация | Abstract-teg-secretion-color_REVIEW-BIS.tif | 19,8 МБ | 30 апреля 2021 [nbiserova] |