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Brain-related genes are specifically enriched with long phase 1 intronsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 апреля 2021 г.
- Авторы: Baulin Eugene F., Kulakovskiy Ivan V., Roytberg Mikhail A., Astakhova Tatiana V.
- Журнал: PLoS ONE
- Том: 15
- Номер: 5
- Год издания: 2020
- Издательство: Public Library of Science
- Местоположение издательства: United States
- Первая страница: e0233978
- Последняя страница: e0233978
- DOI: 10.1371/journal.pone.0233978
- Аннотация: Intronic gene regions are mostly considered in the scope of gene expression regulation, such as alternative splicing. However, relations between basic statistical properties of introns are much rarely studied in detail, despite vast available data. Particularly, little is known regarding the relationship between the intron length and the intron phase. Intron phase distribution is significantly different at different intron length thresholds. In this study, we performed GO enrichment analysis of gene sets with a particular intron phase at varying intron length thresholds using a list of 13823 orthologous human-mouse gene pairs. We found a specific group of 153 genes with phase 1 introns longer than 50 kilobases that were specifically expressed in brain, functionally related to synaptic signaling, and strongly associated with schizophrenia and other mental disorders. We propose that the prevalence of long phase 1 introns arises from the presence of the signal peptide sequence and is connected with 1–1 exon shuffling.
- Добавил в систему: Баулин Евгений Федорович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | pone.0233978.pdf | 952,0 КБ | 11 апреля 2021 [febos] |