Metal complexes with functionalised 2,2'-dipicolylamine ligand containing an antioxidant 2,6-di-tert-butylphenol moiety: synthesis and biological studies

Milaeva, E.R.; Shpakovsky, D.B.; Gracheva, Y.A.; Orlova, S.I.; Maduar, V.V.; Tarasevich, B.N.; Meleshonkova, N.N.; Dubova, L.G.; Shevtsova, E.F.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.

Авторы: Milaeva Elena R., Shpakovsky Dmitry B., Gracheva Yulia A., Orlova Sophia I., Maduar Viktoryia V., Tarasevich Boris N., Meleshonkova Natalia N., Dubova Ludmila G., Shevtsova Elena F.
Журнал: Dalton Transactions
Том: 42
Номер: 19
Год издания: 2013
Издательство: Royal Society of Chemistry
Местоположение издательства: United Kingdom
Первая страница: 6817
Последняя страница: 6828
DOI: 10.1039/C3DT50160D
Аннотация: A series of Zn, Mn, Fe, Co, and Ni complexes ([MX2L], X = Cl, OAc) of the novel di-(2-picolyl)amine ligand L with an antioxidant 2,6-di-tert-butylphenol pendant were synthesized and characterized by elemental analysis, IR, multinuclear NMR spectroscopy, MALDI-TOF mass spectrometry and the molecular structures of [ZnCl2L] and [MnCl2L] were established by X-ray crystallography. The chemical oxidation of complexes with a 2,6-di-tert-butylphenol fragment to the phenoxyl radicals was studied by means of ESR method. The antioxidant radical scavenging activity of the complexes was measured spectrophotometrically using a DPPH-test and linoleic acid peroxidation. The electron transfer reactions were examined in CUPRAC tests and as the inhibition of an enzymatic reaction involving the generation of a reactive oxygen species (superoxide radical-anion) by xanthine oxidase. The lipoxygenase (LOX) inhibition activity of the studied compounds was evaluated. The in vitro biological experiments were performed by using rat brain homogenates. The role of the phenol fragment and metal was found to be essential in antioxidant activity.
Добавил в систему: Шпаковский Дмитрий Борисович

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Metal complexes with functionalised 2,2'-dipicolylamine ligand containing an antioxidant 2,6-di-tert-butylphenol moiety: synthesis and biological studiesстатья

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