General features of the energetics of complex formation between ligand and nucleic acidsстатья
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 апреля 2017 г.
Авторы:
Kostjukov V.V. ,
Rogova O.V. ,
Evstigneev M.P.
Журнал:
Biophysics
Том:
59
Номер:
4
Год издания:
2014
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
546
Последняя страница:
551
DOI:
10.1134/S0006350914040149
Аннотация:
The analysis of the energy contributions of various physical factors to the complex formation between biologically active compounds and nucleic acids in aqueous solution was performed. A comparison of the energy parameters was made for ligand-ligand, intercalator-DNA, MGB-DNA and ligand-RNA groups. It was shown that the energetics of these reactions is of compensatory nature. Physical factors exerting the most pronounced influence on the energy parameters were identified. Correlation of the energy contributions to MGB-DNA complex formation and its biological effect was found. © 2014, Pleiades Publishing, Inc.
Добавил в систему:
Евстигнеев Максим Павлович