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Studies by means of 1H NMR spectroscopy of complex formation of aromatic biologically active compounds with antibiotic topotecanстатья
- Авторы: Mosunov A.A., Kostjukov V.V., Evstigneev M.P.
- Журнал: UKRAINSKII KHIMICHESKII ZHURNAL
- Том: 84
- Номер: 2
- Год издания: 2012
- Первая страница: 61
- Последняя страница: 72
- Аннотация: The analysis of heteroassociation of antibiotic topotecan (TpT) with aromatic biologically active compounds (BAC): caffeine, mutagens ethidium bromide and proflavine, antibiotic daunomycin, vitamins flavin-mononucleotide and nicotinamide, has been carried out in the work using 1H NMR spectroscopy data. The equilibrium constants of heteroassociation and induced chemical shifts of the protons have been obtained in the complexes with BAC. It is found that the complex formation TpT-BAC has the nature of stacking of the chromophores, additionally stabilized in the case of proflavine by intermolecular hydrogen bond. Calculation of the basic components of the Gibbs free energy of the complexation reactions is carried out, and the factors which stabilize and destabilize the heterocomplexes of molecules are revealed.
- Добавил в систему: Евстигнеев Максим Павлович