Contribution of enthalpy to the energetics of complex formation of aromatic ligands with DNAстатья
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Дата последнего поиска статьи во внешних источниках: 11 апреля 2017 г.
Авторы:
Kostyukov V.V.,
Khomutova N.M. ,
Evstigneev M.P.
Журнал:
Biophysics
Том:
56
Номер:
4
Год издания:
2011
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
634
Последняя страница:
643
DOI:
10.1134/S0006350911040117
Аннотация:
The energy contributions of electrostatic, van der Waals interactions, hydrogen bonds, and interactions of charge transfer type to the enthalpy of complex formation of the double-stand DNA with the antitumor antibiotics daunomycin, nogalamycin, and novantron, as well as the mutagens ethidium bromide and proflavine have been calculated. According to the calculations, the van der Waals component (except for nogalamycin) is energetically favorable during complex formation of the antibiotics with DNA, and the contributions of H bonds and electrostatic interactions are unfavorable, with the probability of charge transfer in the complexes being low. It has been shown that the relatively low value of the experimental enthalpy of binding is the sum of components greater in absolute value and different in the sign, which is the cause of large errors in estimating the total enthalpy of complex formation of aromatic ligands with DNA. © 2011 Pleiades Publishing, Ltd.
Добавил в систему:
Евстигнеев Максим Павлович