Аннотация:Early prediction of obesity risk will be facilitated by the identification of the main genes and their relevant
genetic variants. Outstanding among the many genes associated with obesity is the FTO gene. SNP’s in the
first intron of the FTO gene are associated with overweight and obesity risk. The FTO T/A-polymorphism has
emerged as one of the most important obesity susceptibility gene variants known to date, which has been
studied in different ethnicities, among obese people and people with metabolic syndrome, and among cohorts
with different socioeconomic status. The aim of the present paper was to study associations between T/Apolymorphism
of the FTO gene and obesity-related morphological traits in youngsters of both sexes.
227 students of different Saransk universities (122 females and 105 males), aged from 17 to 23 years,
took part in the investigation. The program included anthropometric measurements (30), and the collection of
buccal smears for genetic analysis (FTO, rs9939609). Distribution of the genotype frequencies is consistent
with Hardy–Weinberg equilibrium, and, in general, is the same as in the European populations. Significant
differences are revealed for obesity-related morphological traits: in the male subgroup AA genotype carriers
have increased total body fat accumulation, higher waist-to-hip ratio with primary abdominal fat accumulation.
In the female subgroup these trends are not statistically significant. But female students with AA genotype
demonstrate higher values for skinfold thickness and increased waist-to-hips ratio. It is possible that individual
predisposition to overweight and obesity will appear in female carriers of the risk genotype later with age.
Keywords: anthropogenetics, FTO gene polymorphism, obesity, abdominal obesity, morphological traits