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Two Anhydrous and a Trihyd rate Form of Tilorone Dihydrochloride: Hydrogen-Bonding Patterns and Reversible Hydration/Dehydration Solid-State Transformationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Chernyshev Vladimir V., Yatsenko Alexandr V., Pirogov Sergey V., Nikulenkova Tamara F., Tumanova Ekaterina V., Lonin Ivan S., Paseshnichenko Ksenia A., Mironov Andrei V., Velikodny Yurii A.
- Журнал: Crystal Growth and Design
- Том: 12
- Номер: 12
- Год издания: 2012
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 6118
- Последняя страница: 6125
- DOI: 10.1021/cg3012475
- Аннотация: During the polymorph screening of an active pharmaceutical ingredient tilorone dihydrochloride (chemical name 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride) two new polymorphic modifications - III and IV - were obtained. The crystal structures of both polymorphs were established from X-ray powder diffraction. An interesting phenomenon has been observed at ambient conditions for III, which transforms into a novel hydrated form IIIh during 2-3 h when the humidity in the storage room increases to 70% or more. As soon as the relative humidity falls to 30% or less, IIIh transforms into the parent anhydrous form III within an hour. Form IIIh has been identified as a trihydrate of tilorone dihydrochloride, and its crystal structure has been established from X-ray powder diffraction. On the basis of the crystal structures and hydrogen-bonding patterns, a mechanistic model of reversible hydration/dehydration solid-state transformation III <-> IIIh depending on the relative humidity is proposed.
- Добавил в систему: Пасешниченко Ксения Андреевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | crystal-growth.pdf | 3,8 МБ | 7 мая 2014 [PaseshnichenkoKseniaAndreevna] |