Аннотация:Modern architectures of central processors, in particular, AMD Zen 2 and Intel Cascade Lake, allow one to build shared memory systems with more than 100 computational cores. This paper presents the results of comparing the performance of these architectures shown on numerical modeling of mitosis in eukaryotes. The MiCoSi software that was developed by the authors and previously demonstrated a linear scalability when executed on cluster systems was used as a benchmark. The testing was performed on Amazon EC2 cloud nodes with 96 logical cores each. It is shown that, in relation to the problem of mitosis modeling, the two architectures under study have similar performance, while in some cases, Intel Cascade Lake bypasses its competitor AMD Zen 2 by 5-23%.