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Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensisстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 июля 2021 г.
- Авторы: Grigoreva Anastasiia, Andreeva Julia, Bikmetov Dmitry, Rusanova Anastasiia, Serebryakova Marina, Garcia Andrea Hernandez, Slonova Darya, Nair Satish K., Lippens Guy, Severinov Konstantin, Dubiley Svetlana
- Журнал: iScience
- Том: 24
- Номер: 5
- Год издания: 2021
- Издательство: Cell Press
- Местоположение издательства: United States
- Номер статьи: 102480
- DOI: 10.1016/j.isci.2021.102480
- Аннотация: Lanthipeptides, ribosomally synthesized and post-translationally modified peptides (RiPPs), can be divided into five classes based on their structures and biosynthetic pathways. Class I and II lanthipeptides have been well characterized, whereas less is known about members of the other three classes. Here, we describe a new family of class III lanthipeptides from Firmicutes. Members of the family are distinguished by the presence of a single carboxy-terminal labionin. We identified and characterized andalusicin, a representative of this family. Andalusicin bears two methyl groups at the α-amino terminus, a post-translational modification that has not previously been identified in class III lanthipeptides. Mature andalusicin A shows bioactivity against various Gram-positive bacteria, an activity that is highly dependent on the α-N dimethylation.
- Добавил в систему: Серебрякова Марина Васильевна