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Antibacterial Poly(ε‐CL)/Hydroxyapatite Electrospun Fibers Reinforced by Poly(ε‐CL)‐b‐Poly(Ethylene Phosphoric Acidстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 августа 2021 г.
- Авторы: Nifant’ev Ilya, Gavrilov Dmitry, Tavtorkin Alexander, Chinova Maria, Besprozvannykh Victoria, Komarov Pavel, Zaitsev Vladimir, Podoprigora Irina, Ivchenko Pavel
- Журнал: International Journal of Molecular Sciences
- Том: 22
- Номер: 14
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 7690
- Последняя страница: 7690
- DOI: 10.3390/ijms22147690
- Аннотация: In bone surgery and orthopedics, bioresorbable materials can be helpful in bone repairand countering post‐op infections. Explicit antibacterial activity, osteoinductive and osteoconductive effects are essential to achieving this objective. Nonwoven electrospun (ES) fibers are receiving the close attention of physicians as promising materials for wound dressing and tissue engineering; potentially, in high contrast with dense materials, ES mats hamper regeneration of the bone extracellular matrix to a lesser extent. The use of the compositions of inherently biodegradable polyesters (poly(ε‐caprolactone) PCL, poly(lactoglycolide), etc.), calcium phosphates and antibiotics is highly prospective, but the task of forming ES fibers from such compositions is complicated by the incompatibility of the main organic and inorganic ingredients, polyesters and calcium phosphates. In the present research we report the synthesis of hydroxyapatite (HAp) nanoparticles with uniform morphology, and demonstrate high efficiency of the block copolymer of PCL and poly(ethylene phosphoric acid) (PEPA) as an efficient compatibilizer for PCL/HAp mixtures that are able to form ES fibers with improved mechanical characteristics. The materials obtained in the presence of vancomycin exhibited incremental drug release against Staphylococcus aureus (St. aureus).
- Добавил в систему: Ивченко Павел Васильевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2021_International_Journal_of_Molecular_Sciences_22_14_7690… | 4,1 МБ | 20 июля 2021 [Pavel_V_Ivchenko] |