Effects of alpha-2 Adrenergic agonist mafedine on brain electrical activity in rats after traumatic brain injury

Sysoev, Y.I.; Prikhodko, V.A.; Chernyakov, R.T.; Idiyatullin, R.D.; Musienko, P.E.; Okovityi, S.V.

Авторы: Sysoev Yu I., Prikhodko V.A., Chernyakov R.T., Idiyatullin R.D., Musienko P.E., Okovityi S.V.
Журнал: BRAIN SCIENCES
Том: 11
Номер: 8
Год издания: 2021
Номер статьи: 981
DOI: 10.3390/brainsci11080981
Аннотация: The search for and development of new neuroprotective (or cerebroprotective) drugs, aswell as suitable methods for their preclinical efficacy evaluation, are priorities for current biomedical research. Alpha-2 adrenergic agonists, such as mafedine and dexmedetomidine, are a highlyappealing group of drugs capable of reducing neurological deficits which result from brain trauma and vascular events in both experimental animals and human patients. Thus, our aim was to assess the effects of mafedine and dexmedetomidine on the brain’s electrical activity in a controlledcortical-impact model of traumatic brain injury (TBI) in rats. The functional status of the animals was assessed by electrocorticography (ECoG), using ECoG electrodes which were chronically implantedin different cortical regions. The administration of intraperitoneal mafedine sodium at 2.5 mgkg􀀀1 at 1 h after TBI induction, and daily for the following 6 days, restored interhemispheric connectivity in remote brain regions and intrahemispheric connections within the unaffected hemisphere at post-TBI day 7. Animals that had received mafedine sodium also demonstrated an improvement in cortical responses to photic and somatosensory stimulation. Dexmedetomidine at 25 gkg􀀀1 did not affect the brain’s electrical activity in brain-injured rats. Our results confirm the previously described neuroprotective effects of mafedine sodium and suggest that ECoG registration and analysis are aviable method evaluating drug efficacy in experimental animal models of TBI.
Добавил в систему: Оковитый Сергей Владимирович

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Effects of alpha-2 Adrenergic agonist mafedine on brain electrical activity in rats after traumatic brain injuryстатья

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