GENDER-DEPENDENT ACTIONS OF THE HISTONE DEACETYLASE BLOCKER SODIUM VALPROATE ON OLFACTORY LEARNING IN 129SV MICE DURING THE EARLY POSTNATAL PERIOD

Burenkova, O.V.; Aleksandrova, E.A.; Zaraiskaya, I.Y.

Авторы: Burenkova O.V., Aleksandrova E.A., Zaraiskaya I.Y.
Журнал: Neuroscience and Behavioral Physiology
Том: 44
Номер: 9
Год издания: 2014
Издательство: Kluwer Academic/Plenum Publishers
Местоположение издательства: United States
Первая страница: 1008
Последняя страница: 1013
Аннотация: In the brain, histone acetylation underlies both learning and the maintenance of long-term sustained effects of early experience which is further epigenetically inherited. However, the role of acetylation in learning previously has only been studied in adult animals: high level of learning could be dependent on high levels of histone H3 acetylation in the brain. The role of acetylation in the mechanisms of early learning has not been studied. In the present work, we were interested whether histone deacetylase inhibitor sodium valproate which increases the level of histone H3 acetylation will affect early olfactory discrimination learning in 8-day-old pups of 129Sv mice that are characterized by low efficiency of learning with imitation of maternal grooming. Multiple valproate injections from 3rd to 6th postnatal day had a gender-dependent effect: learning was selectively improved in male but not in female pups. In the female pups, learning improvement was observed after multiple injections of saline. Possible epigenetic mechanisms underlying these sex differences are discussed.
Добавил в систему: Буренкова Ольга Владимировна

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GENDER-DEPENDENT ACTIONS OF THE HISTONE DEACETYLASE BLOCKER SODIUM VALPROATE ON OLFACTORY LEARNING IN 129SV MICE DURING THE EARLY POSTNATAL PERIODстатья