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RATIO OF REDUCED AND OXIDIZED THIOL COMPOUNDS IN PATIENTS WITH T2DM AND WITH MICROANGIOPATHY OF LOWER EXTREMITIES AFTER N-ACETYLCYSTEINE THERAPYстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 сентября 2021 г.
- Авторы: Darenskaya M.A., Shemyakina N.A., Namokonov E.V., Kolesnikov S.I., Kolesnikova L.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 23
- Номер: s2
- Год издания: 2021
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: 234
- Последняя страница: 234
- DOI: 10.1089/dia.2021.2525
- Аннотация: Background and Aims: Vascular complications are the disability and mortality main cause in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess the CysSH/CysSSCys and GSH/GSSG ratio change in patients with T2DM and microangiopathy of the lower extremities after N‐acetylcysteine therapy.Methods: 40 men with T2DM and microangiopathy of the lower extremities (the main group) and 30 healthy men (control group) were involved. Depending on the chosen treatment and the therapy, patients of main group were divided into 2 subgroups of 20 people. In the 1st subgroup, Sol.Octolipeni 600 mg, once a day, intravenously for 7 days was prescribed in complex therapy. In the 2nd subgroup, the introduction of Sol. N‐acetylcysteine (NAC) in a daily dose of 600 mg, once a day, intravenously, for 7 days was additionally applied. High‐performance liquid chromatography was determined.Results: The value of the CysSH/CysSSCys ratio in the control group was 2.1 units, in main group it was only 0.7 units, relative to the control. In the control group, the GSH/GSSG coefficient was 20 units, in main group – 3.3 times less than the control values. When conducting therapy with the inclusion of NAC, more pronounced changes in the studied parameters were revealed compared to therapy with α‐lipoic acid. Thus, the coefficients increased by 2.5 and 3.3 times, respectively. CysSH/CysSSCys becomes 1.8 ± 0.3 units, GSH/GSSG increases to 20 ± 0.3 units.Conclusions: NAC contributes to an increase in the values of reduced cysteine and glutathione fractions at patients with T2DM and microangiopathy of the lower extremities.
- Добавил в систему: Колесников Сергей Иванович