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Key Immune Checkpoint PD-1/PD-L1 Signaling Pathway Components in the Blood Serum from Patients with Bone Tumorsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
- Авторы: Kushlinskii N.E., Alferov A.A., Timofeev Y.S., Gershtein E.S., Bulycheva I.V., Bondarev A.V., Shchupak M.Y., Sokolov N.Y., Polikarpova S.B., Efimova M.M., Dzampaev A.A., Sushentsov E.A., Aliev M.D., Musaev E.R.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 170
- Номер: 1
- Год издания: 2020
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 64
- Последняя страница: 68
- DOI: 10.1007/s10517-020-05005-2
- Аннотация: The levels of sPD-1 and sPD-L1 were analyzed in blood serum of 132 patients (age 14-70 years) with primary bone tumors: osteosarcoma (N=39), chondrosarcoma (N=42), Ewing sarcoma (N=9), chordoma (N=12), giant-cell bone tumor (GCBT) (N=16), benign neoplasms (N=14) and in and practically healthy subjects (age 19-58 years; N=27). sPD-L1 levels in all studied bone neoplasms were significantly higher than in the control. Serum sPD-1 level in GCBT patients was significantly higher than in the control, benign neoplasms, chondrosarcoma, and chordoma patients, but did not differ from osteosarcoma group. sPD-1 concentration in Ewing sarcoma was significantly higher than in chordoma and chondrosarcoma, but did not differ from the control. sPD-1 level in chondrosarcoma patients was also lower than in osteosarcoma, Ewing sarcoma, and in the control. Both sPD-1 and sPD-L1 concentrations were not significantly associated with the type of affected bone, process localization, disease stage, tumor histological grade, patients’ age and sex. These results suggest the possibility of using these biological markers for preliminary assessment of the character of the process in the bone. В© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
- Добавил в систему: Герштейн Елена Сергеевна