Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphateстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Аннотация:For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistanceand the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work,brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCPwere prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, andcompressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture ofbrushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, andPseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblastNCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to theβ-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.