RAP80-DIRECTED TUNING OF BRCA1 HOMOLOGOUS RECOMBINATION FUNCTION AT IONIZING RADIATION-INDUCED NUCLEAR FOCI

Hu, Y.; Scully, R.; Sobhian, B.; Xie, A.; Shestakova, E.; Livingston, D.M.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.

Авторы: Hu Y., Scully R., Sobhian B., Xie A., Shestakova E., Livingston D.M.
Журнал: Genes and Development
Том: 25
Номер: 7
Год издания: 2011
Издательство: Cold Spring Harbor Laboratory Press
Местоположение издательства: United States
Первая страница: 685
Последняя страница: 700
DOI: 10.1101/gad.2011011
Аннотация: In response to DNA double-strand breaks (DSBs), BRCA1 forms biochemically distinct complexes with certainother DNA damage response proteins. These structures, some of which are required for homologous recombination(HR)-type DSB repair, concentrate at distinct nuclear foci that demarcate sites of genome breakage.Polyubiquitin binding by one of these structures, the RAP80/BRCA1 complex, is required for efficient BRCA1focal recruitment, but the relationship of this process to the execution of HR has been unclear. We found that thiscomplex actively suppresses otherwise exaggerated, BRCA1-driven HR. By controlling the kinetics by which otherBRCA1-interacting proteins that promote HR concentrate together with BRCA1 in nuclear foci, RAP80/BRCA1complexes suppress excessive DSB end processing, HR-type DSB repair, and overt chromosomal instability. Sincechromosomal instability emerges when BRCA1 HR function is either unbridled or absent, active tuning of BRCA1activity, executed in nuclear foci, is important to genome integrity maintenance.Keywords: BRCA1; RAP80; homologous recombination; ionizing radiation-induced foci
Добавил в систему: Шестакова Елена Анатольевна

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RAP80-DIRECTED TUNING OF BRCA1 HOMOLOGOUS RECOMBINATION FUNCTION AT IONIZING RADIATION-INDUCED NUCLEAR FOCIстатья Исследовательская статья

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