Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging

Sanzhakov, M.A.; Kudinov, V.A.; Baskaev, K.K.; Morozevich, G.E.; Stepanova, D.S.; Torkhovskaya, T.I.; Tereshkina, Y.A.; Korotkevich, E.I.; Tikhonova, E.G.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.

Авторы: Sanzhakov M.A., Kudinov V.A., Baskaev K.K., Morozevich G.E., Stepanova D.S., Torkhovskaya T.I., Tereshkina Yu A., Korotkevich E.I., Tikhonova E.G.
Журнал: Biomedicine and Pharmacotherapy
Том: 142
Год издания: 2021
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 111985
DOI: 10.1016/j.biopha.2021.111985
Аннотация: Gold nanoparticles and their conjugates have significant potential in the field of diagnosis of various diseases due to their SPR, which enhances light scattering and absorption. Conjugates of gold nanoparticles with various ligands can be used for imaging biomolecules or detecting malignant neoplasms at an early stage. This study focuses on the construction of composite (or hybrid) phospholipid-gold nanoparticles using soy phosphatidylcholine and a targeted ligand (folic acid derivative) to attach specific targeting properties. According to the method of dynamic light scattering, the diameter of the obtained nanoparticles was less than 100 nm, the results of the MTT test indicated their moderate cytotoxicity. In vitro and in vivo experiments showed a significant increase in the accumulation of phospholipid-gold nanoparticles with a targeted fragment compared to those without a targeted fragment both in HeLa cells and in a tumor (in BDF mice with an injected LLC tumor). The resulting nanoparticles are suitable for specific delivery into tumor cells and visualization of various malignant neoplasms, including at early stages, due to the increased expression of the folate receptor characteristic of cells of a wide range of tumors.
Добавил в систему: Кудинов Василий Андреевич

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Composite phospholipid-gold nanoparticles with targeted fragment for tumor imagingстатья

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