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Early Induction of Neurotrophin Receptor and miRNA Genes in Mouse Brain after Pentilenetetrazole-Induced Neuronal Activityстатья Исследовательская статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 ноября 2021 г.
- Авторы: Shmakova A.A., Rysenkova K.D., Ivashkina O.I., Gruzdeva A.M., Klimovich P.S., Popov V.S., Rubina K.A., Anokhin K.V., Tkachuk V.A., Semina E.V.
- Журнал: Biochemistry (Moscow)
- Том: 86
- Номер: 10
- Год издания: 2021
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1326
- Последняя страница: 1341
- DOI: 10.1134/S0006297921100138
- Аннотация: Neurotrophin receptors regulate neuronal survival and network formation, as well as synaptic plasticity in the brain via interaction with their ligands. Here, we examined early changes in the expression of neurotrophin receptor genes Ntk1 (TrkA), Ntrk2 (TrkB), Ntrk3 (TrkC), Ngfr (p75NTR) and miRNAs that target theses gens in the mouse brain after induction of seizure activity by pentylenetetrazol. We found that expression of Ntrk3 and Ngfr was upregulated in the cortexand the hippocampus 13 hours after the seizures, while Ntrk2 expression increased after 36 hours in the anterior cortexand after 1 and 6 hours in the hippocampus. At the same time, the ratio of Bcl-2/Bax signaling proteins increased in the anterior and posterior cortex, but not in the hippocampus, suggesting the activation of anti-apoptotic signaling. Expression of miRNA-9 and miRNA-29a, which were predicted to target Ntrk3, was upregulated in the hippocampus 3 hours afterpentylenetetrazol injection. Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3,Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity.
- Добавил в систему: Семина Екатерина Владимировна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Shmakova_ert_al_Early_Induction_of_Neurotrophin_Receptor.pdf | 2,1 МБ | 9 октября 2021 [e-semina@yandex.ru] | |
| 2. | Shmakova_et_al__Supplement_Early_Induction_of_Neurotrophin_… | Shmakova_et_al__Supplement_Early_Induction_of_Neurotrophin_… | 2,9 МБ | 9 октября 2021 [e-semina@yandex.ru] |