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10(6′Plastoquinonyl)decyltriphenylphosphonium (SkQ1) Does Not Increase the Levelof Cytochromes P450 in Rat Liver and Human Hepatocyte Cell Cultureстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2017 г.
- Авторы: K Myasoedova N.K.N, Silachev D.N., Petrov A.D.
- Журнал: Biochemistry (Moscow)
- Том: 81
- Номер: 12
- Год издания: 2016
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1488
- Последняя страница: 1492
- DOI: 10.1134/S0006297916120105
- Аннотация: Mitochondriatargeted antioxidant SkQ1 did not increase the content of cytochromes P450 in livers of rats that were given SkQ1 in drinking water for 5 days in a dose (2.5 μmol per kg body weight) that exceeded 10 times the SkQ1 ther apeutic dose. SkQ1 did not affect the levels of cytochrome P450 forms CYP1A2, CYP2B6, and CYP3A4 in monolayer cultures of freshly isolated human hepatocytes, while specific inducers of these forms (omeprazole, phenobarbital, and rifampicin, respectively) significantly increased expression of the cytochromes P450 under the same conditions. We conclude that therapeutic doses of SkQ1 do not induce cytochromes P450 in liver, and the absence of the inducing effect can not be explained by poor availability of hepatocytes to SkQ1 in vivo.
- Добавил в систему: Силачёв Денис Николаевич