Diverse Repertoire of the MHC Class II-Peptide Complexes Is Required for Presentation of Viral Superantigens

Golovkina, T.V.; Agafonova, Y.; Kazansky, D.; Chervonsky, A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 октября 2021 г.

Авторы: Golovkina Tatyana V., Agafonova Yelena, Kazansky Dmitry, Chervonsky Alexander
Журнал: Journal of Immunology
Том: 166
Номер: 4
Год издания: 2001
Издательство: American Association of Immunologists
Местоположение издательства: United States
Первая страница: 2244
Последняя страница: 2250
DOI: 10.4049/jimmunol.166.4.2244
Аннотация: Among other features, peptides affect MHC class II molecules, causing changes in the binding of bacterial superantigens (b-Sag). Whether peptides can alter binding of viral superantigens (v-Sag) to MHC class II was not known. Here we addressed the question of whether mutations limiting the diversity of peptides bound by the MHC class II molecules influenced the presentation of v-Sag and, subsequently, the life cycle of the mouse mammary tumor virus (MMTV). T cells reactive to v-Sag were found in mice lacking DM molecules as well as in A(b)Ep-transgenic mice in which MHC class II binding grooves were predominantly occupied by an invariant chain fragment or Ealpha(52-68) peptide, respectively. APCs from the mutant mice failed to present v-Sag, as determined by the lack of Sag-specific T cell activation, Sag-induced T cell deletion, and by the aborted MMTV infection. In contrast, mice that express I-A(b) with a variety of bound peptides presented v-Sag and were susceptible to MMTV infection. Comparison of v-Sag and b-Sag presentation by the same mutant cells suggested that presentation of v-Sag had requirements similar to that for presentation of toxic shock syndrome toxin-1. Thus, MHC class II peptide repertoire is critical for recognition of v-Sag by the T cells and affects the outcome of infection with a retrovirus.
Добавил в систему: Казанский Дмитрий Борисович

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Diverse Repertoire of the MHC Class II-Peptide Complexes Is Required for Presentation of Viral Superantigensстатья Исследовательская статья

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