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Functional characteristics of liver T-lymphocytes in allogenic response to mutant class I and II MHC moleculesстатья Перевод
Дата последнего поиска статьи во внешних источниках: 14 октября 2021 г.
- Авторы: Chernyshova A.D., Brondz B.D., Anosova N.G., Boiko R.Z., Aizenberg L.V., Kazanskii D.B.
- Журнал: Molecular Biology
- Том: 30
- Номер: 3 SUPPL. 2
- Год издания: 1996
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 429
- Последняя страница: 433
- Аннотация: Assessment of the allogenic proliferative response of different subpopulations (CD4+, CD8+, CD4-CD8-) of liver T-lymphocytes to class I and II mutant MHC molecules showed that, like peripheral T-lymphocytes, liver T-lymphocytes CD4+ recognized class II but not class I, whereas CD8+ recognized class I but not II. Monoclonal antibodies against CD4 and CD8 coreceptors selectively inhibited the response of liver T-lymphocytes to mutant MHC molecules of class II and I, respectively. Spleen lymphocytes CD4-CD8- did not proliferate in their response to alloantigens. On the contrary, removal of CD4+ and CD8+ T-cells from the liver lymphocyte population did not completely abolish the response. Thus, the primary proliferative allogenic response of liver lymphocytes was in agreement with the classical scheme of MHC-restricted recognition, and thymus should be considered the most probable source of alloreactive liver T-lymphocytes.
- Добавил в систему: Казанский Дмитрий Борисович