Suppression of primary allogenic response by CD8+ memory cellsстатья
Перевод
Исследовательская статья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 октября 2021 г.
Авторы:
Grinenko T.S. ,
Pobezinskaya E.L. ,
Pobezinskii L.A. ,
Baturina I.A. ,
Zvezdova E.S. ,
Kazanskii D.B.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
140
Номер:
5
Год издания:
2005
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
545
Последняя страница:
549
DOI:
10.1007/s10517-006-0020-8
Аннотация:
Immune response to allogenic tumor cells is associated with the appearance of long-living CD8+ memory cells capable of rapid restimulation and lysis of tumor cells in case of repeated injection of these cells. In order to acquire the effector function, allorestricted memory cells need antigen restimulation for 2 days, which is a specific feature of central memory cell population. These cells can suppress proliferation of naive splenocytes in vitro. In mixed lymphocyte cultures containing memory cells, antigen stimulation induces more intensive IL-10 production and deeper suppression of IL-2 production in comparison with cultures containing naive cells. The conditions for activation of naive cells during secondary immune response are not optimal. © 2005 Springer Science+Business Media, Inc.
Добавил в систему:
Казанский Дмитрий Борисович