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A nonhuman primate model of early effects of irradiation with high-energy protons on operator activityстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
- Авторы: Latanov A.V., Shamsiev I.D., Tereshenko L.V.
- Сборник: IOP Conf. Series: Earth and Environmental Science
- Том: 853
- Глава в коллективной монографии
- Год издания: 2021
- Издательство: IOP Publishing
- Местоположение издательства: [Bristol, UK], England
- Номер статьи: 012021
- DOI: 10.1088/1755-1315/853/1/012021
- Аннотация: During long-term space missions irradiation with Galactic Cosmic Rays may result in acute damage to human central nervous system (CNS) and, possibly, lead to disturbances of operator activity. Three monkeys (Macaca mulatta) were trained to perform a visuomotor task consisting of saccade and manual responses to visual stimuli, thus constituting a model of operator activity. Upon training completion two animals (M1 and M2) were exposed to cranial irradiation with high-energy protons (170 MeV, 3 Gy), while the third (M3) underwent selective irradiation of parietal lobe in Bragg peak (155 MeV, 3 Gy). We noticed no change in instrumental task performance in course of three months after irradiation (a.i.). Both cranially irradiated animals demonstrated a highly correlated increase in both saccade and manual response latencies one month a.i. M3 experienced earlier and stronger increase in these parameters starting on the 20th day a.i. Our results suggest that systemic behavioural mechanisms are resistant to proton irradiation while visual motor integration and executive control systems might be affected, resulting in reaction time increase.
- Добавил в систему: Латанов Александр Васильевич