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Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorderстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
- Авторы: Babenko VN, Smagin DA, Galyamina AG, Kovalenko IL, Kudryavtseva NN
- Журнал: BMC Neuroscience
- Том: 19
- Номер: 1
- Год издания: 2018
- Издательство: BioMed Central
- Местоположение издательства: London
- Номер статьи: 79
- DOI: 10.1186/s12868-018-0480-6
- Аннотация: Background: Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the diferentially expressed Slc25* family genes encoding mitochondrial carrier proteins were analyzed in the brain of depressive (defeated) mice versus aggressive mice winning in everyday social confrontations. The collected samples of brain regions were sequenced at JSC Genoanalytica (http://genoanalytica.ru/, Moscow, Russia).Results: Changes in the expression of the 20 Slc25* genes in the male mice were brain region- and social experience (positive or negative)-specifc. In particular, most Slc25* genes were up-regulated in the hypothalamus of defeated and aggressive mice and in the hippocampus of defeated mice. In the striatum of defeated mice and in the ventral tegmental area of aggressive mice expression of mitochondrial transporter genes changed specifcally. Signifcant correlations between expression of most Slc25* genes and mitochondrial Mrps and Mrpl genes were found in the brain regions.Conclusion: Altered expression of the Slc25* genes may serve as a marker of mitochondrial dysfunction in brain, which accompanies the development of many neurological and psychoemotional disorders
- Добавил в систему: Галямина Анна Георгиевна