Effective Degradation of Gluten and Its Fragments by Gluten-Specific Peptidases: A Review on Application for the Treatment of Patients with Gluten Sensitivity

Dunaevsky, Y.E.; Tereshchenkova, V.F.; Belozersky, M.A.; Filippova, I.Y.; Oppert, B.; Elpidina, E.N.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 декабря 2021 г.

Авторы: Dunaevsky Yakov E., Tereshchenkova Valeriia F., Belozersky Mikhail A., Filippova Irina Y., Oppert Brenda, Elpidina Elena N.
Журнал: Pharmaceutics
Том: 13
Номер: 10
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1603
DOI: 10.3390/pharmaceutics13101603
Аннотация: Abstract: To date, there is no effective treatment for celiac disease (CD, gluten enteropathy), anautoimmune disease caused by gluten-containing food. Celiac patients are supported by a strictgluten-free diet (GFD). However, in some cases GFD does not negate gluten-induced symptoms.Many patients with CD, despite following such a diet, retain symptoms of active disease due tohigh sensitivity even to traces of gluten. In addition, strict adherence to GFD reduces the quality oflife of patients, as often it is difficult to maintain in a professional or social environment. Variouspharmacological treatments are being developed to complement GFD. One promising treatment isenzyme therapy, involving the intake of peptidases with food to digest immunogenic gluten peptidesthat are resistant to hydrolysis due to a high prevalence of proline and glutamine amino acids. Thisnarrative review considers the features of the main proline/glutamine-rich proteins of cereals and theconditions that cause the symptoms of CD. In addition, we evaluate information about peptidasesfrom various sources that can effectively break down these proteins and their immunogenic peptides,and analyze data on their activity and preliminary clinical trials. Thus far, the data suggest thatenzyme therapy alone is not sufficient for the treatment of CD but can be used as a pharmacologicalsupplement to GFD.Keywords: celiac disease; peptidases; gluten; enzyme therapy; gluten-free diet
Добавил в систему: Терещенкова Валерия Феликсовна

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Effective Degradation of Gluten and Its Fragments by Gluten-Specific Peptidases: A Review on Application for the Treatment of Patients with Gluten Sensitivityстатья

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