Mechanochemistry for the synthesis of non-classical N-metalated palladium(II) pincer complexes

Aleksanyan, D.V.; Churusova, S.G.; Brunova, V.; Peregudov, A.S.; Shakhov, A.M.; Rybalkina, E.; Klemenkova, Z.; Kononova, E.; Denisov, G.L.; Kozlov, V.A.

Авторы: Aleksanyan Diana V., Churusova Svetlana G., Brunova Valentina, Peregudov Alexander S., Shakhov Aleksander M., Rybalkina Ekaterina, Klemenkova Zinaida, Kononova Elena, Denisov Gleb L., Kozlov Vladimir A.
Журнал: Dalton Transactions
Том: 50
Номер: 45
Год издания: 2021
Издательство: Royal Society of Chemistry
Местоположение издательства: United Kingdom
Первая страница: 16726
Последняя страница: 16738
DOI: 10.1039/d1dt03259c
Аннотация: The peculiarities of cyclopalladation of a series of non-classical pincer-type ligands based on monothiooxalyl amides bearing ancillary N- or S-donor groups in the amide units have been scrutinized both under conditions of conventional solution-based synthesis and in the absence of a solvent according to a solid-phase methodology including mechanochemical activation. Grinding the functionalized monothiooxamides with PdCl2(NCPh)2 in a mortar or vibration ball mill is shown to serve as an efficient and green alternative to the synthesis of these complex metal–organic systems in solution that can offer such advantages as the absence of any auxiliary and significant rate and yield enhancement, especially for the challenging ligands. The realization of S,N,N- or S,N,S-monoanionic tridentate coordination in the resulting pincer complexes has been confirmed by multinuclear NMR (including 2D NMR) and IR spectroscopy and, in some cases, X-ray diffraction. The course and outcome of the solid-phase reactions have been studied by a combination of different spectroscopic methods as well as SEM/EDS analysis. The preliminary evaluation of cytotoxic activity against several human cancer cell lines has revealed the high potency of some of the cyclopalladated derivatives obtained, rendering further development of solvent-free synthetic routes to this type of complexes very urgent.
Добавил в систему: Алексанян Диана Владимировна

	ИСТИНА	Войти в систему Регистрация
	ИПМех РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИПМех РАН

Mechanochemistry for the synthesis of non-classical N-metalated palladium(II) pincer complexesстатья Исследовательская статья

Прикрепленные файлы