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Infection of Human Cells by SARS-CoV-2 and Molecular Overview of Gastrointestinal, Neurological, and Hepatic Problems in COVID-19 Patientsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 декабря 2021 г.
- Авторы: Rahban Mahdie, Stanek Agata, Hooshmand Amirreza, Khamineh Yasaman, Ahi Salma, Kazim Syed Naqui, Ahmad Faizan, Muronetz Vladimir, Abousenna Mohamed Samy, Zolghadri Samaneh, Saboury Ali A.
- Журнал: JOURNAL OF CLINICAL MEDICINE
- Том: 10
- Номер: 21
- Год издания: 2021
- Первая страница: 4802
- DOI: 10.3390/jcm10214802
- Аннотация: The gastrointestinal tract is the body’s largest interface between the host and the external environment. People infected with SARS-CoV-2 are at higher risk of microbiome alterations and severe diseases. Recent evidence has suggested that the pathophysiological and molecular mechanisms associated with gastrointestinal complicity in SARS-CoV-2 infection could be explained by the role of angiotensin-converting enzyme-2 (ACE2) cell receptors. These receptors are overexpressed in the gut lining, leading to a high intestinal permeability to foreign pathogens. It is believed that SARS-CoV-2 has a lesser likelihood of causing liver infection because of the diminished expression of ACE2 in liver cells. Interestingly, an interconnection between the lungs, brain, and gastrointestinal tract during severe COVID-19 has been mentioned. We hope that this review on the molecular mechanisms related to the gastrointestinal disorders as well as neurological and hepatic manifestations experienced by COVID-19 patients will help scientists to find a convenient solution for this and other pandemic events
- Добавил в систему: Муронец Владимир Израилевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | IranSoburykovidcm-10-04802.pdf | IranSoburykovidcm-10-04802.pdf | 17,1 МБ | 9 ноября 2021 [vimuronets] |